MacLellan's Myocardial Regeneration Lab


The main interest in Dr. MacLellan's lab is to understand the molecular mechanisms that regulate cardiac failure and develop therapies to regenerate myocardium. His lab extensively uses genetic mouse models in an attempt to correlate molecular insights with whole organ physiology. The long-term goal of his research to develop stem cell and tissue engineering strategies to repair the heart.

Examples of Lab Work

Adult Human Normal Heart

High-resolution 3D reconstruction of Normal Adult Human Heart 

The hearts were stained for Filamentous Actin (F-actin, Red), glycosylated proteins (WGA, green), DNA (Hoechst, Blue), and mitosis marker phospho-H3 (grayscale).


Genetically enginereed mice heartTransgenic Mouse Model 

Transgenic mouse model with adult CM-specific activation of the Myconcogene results in mitotic activity in adult CMs. Mitotic marker phospho-H3 (white) is shown.

Human Heart Post LVAD

No proliferating CMs were observed, though a proliferative non-CM is shown. The second image is a Human Heart 4 years after LVAD (left ventricular assist device) placement. Post LVAD, no proliferating CMs were observed.

Human Heart 4 years after LVAD placementHuman Heart 4 years after LVAD placement