The main interest in Dr. MacLellan's lab is to understand the molecular mechanisms that regulate cardiac failure and develop therapies to regenerate myocardium. His lab extensively uses genetic mouse models in an attempt to correlate molecular insights with whole organ physiology. The long-term goal of his research to develop stem cell and tissue engineering strategies to repair the heart.

Adult Human Normal Heart
High-resolution 3D reconstruction of Normal Adult Human Heart. The hearts were stained for Filamentous Actin (F-actin, Red), glycosylated proteins (WGA, green), DNA (Hoechst, Blue), and mitosis marker phospho-H3 (grayscale).

Genetically enginereed mice heart
Transgenic mouse model with adult CM-specific activation of the Myc oncogene results in mitotic activity in adult CMs. Mitotic marker phospho-H3 (white) is shown.

Human Heart 4 years after LVAD placement
Human heart post LVAD. No proliferating CMs were observed, though a proliferative non-CM is shown.

Human Heart 4 years after LVAD placement
Human Heart 4 years after LVAD (left ventricular assist device) placement. Post LVAD, no proliferating CMs were observed